Visual ADCADC Formats
Antibody–drug conjugates (ADCs) combine a monoclonal antibody with a cytotoxic payload via a linker. Visual ADC supports calculation and visualization for ADC design and analysis.
DAR (drug-to-antibody ratio)
DAR is the average number of drug molecules per antibody. Typical ADCs have DAR 2–4 for cysteine-conjugated or 2–8 for lysine-conjugated formats. Higher DAR can affect stability and pharmacokinetics. Use the DAR Calculator to compute DAR from antibody and payload inputs.
DAR Calculator →Payload and linker
Payloads are typically cytotoxic small molecules (e.g. MMAE, DM1). Linkers can be cleavable (e.g. protease-sensitive) or non-cleavable. Payload loading and conjugation efficiency influence efficacy and safety. Use Payload Loading and Conjugation Efficiency tools to explore formulations.
Using Visual ADC
Calculate DAR and total molecular weight, visualize ADC 3D structure and payload distribution, and export reports. Data sources include DrugBank, PDB, PubChem, and IMGT.